Children who had fetal valproate exposure had a 48% risk of ADHD compared with unexposed children.

Cumulative Meta-Analysis Carl Heneghan, JK Aronson

First recognition of fetal valproate syndrome in 1986

Neural tube defects in 1994 in the population11.6/10,000 in 1994

Sanofi Patient Information Leaflet - Neural Tube Defects 1% in 1994 (see page 44)

Are patients fully informed of risks of medicines in pregnancy? An IMI ConcePTION study Ulrika Nörby